Xenium In Situ

Unparalleled single cell spatial discovery

Characterize 100s to 1,000s of RNAs in cells and tissues with subcellular in situ resolution.

 

The ultimate single cell spatial biology experience

The Xenium platform delivers high-plex in situ at subcellular resolution with nanometer precision and offers a complete solution, including comprehensive panel offerings, to achieve fast and robust single cell spatial insights.
 

Platform Components

A complete solution from tissue to insight.

Gene & Protein Panels

Choose customizable ready-to-use panels or fully custom gene panels, with add-on protein subpanels.

Xenium Analyzer

A spatial imaging instrument integrating transcript detection, high-resolution imaging, decoding and onboard analysis.

Data Analysis

Use onboard analysis and Xenium Explorer for visualization, exploration and interpretation of spatial data.

Now shipping!

Same-cell spatial multiomics with Xenium Protein

A

A first-of-its-kind fully optimized & automated solution for integrated high-plex spatial RNA and protein expression

B

Validated, ready-to-use immuno-oncology-focused protein and gene panels eliminate the need for optimization

C

Single-instrument workflow enables integrated analysis in Xenium Explorer, no data registration required

Diverse panel menu to fit any research need

<500-gene panels

Focused tissue and pathway characterization

  • Full custom panel option
  • Multiomic analysis with Xenium Protein subpanels

5,000-gene panels

Broad discovery in human and mouse

  • Customizable with up to 100 additional genes
  • Explore across tissues, disease areas, and drug targets

A state-of-the-art single cell spatial imaging instrument

  • Seamlessly integrates transcript detection workflow, high-resolution imaging, decoding, and onboard data analysis for fresh frozen or FFPE tissues
  • Simple run setup and cleanup operations, an intuitive touchscreen, and ergonomic design make instrument operation a breeze
  • Go from tissue section to data for up to 5,000 genes in ≤6 days or get even faster analysis times with smaller gene panels

exploration

Built for rapid data exploration

Immediate data access

Access your data as soon as the Xenium run is complete.

Easy-to-use interface

Intuitively visualize morphology, protein markers, segmentation, cell typing, and transcript density—no bioinformatics experience required.

Explore at any scale

Seamlessly explore your data at any scale, from whole tissue sections to single transcripts.

Resources

See Xenium Protein data in action

Get a hands-on look at what same-section protein and high-plex spatial RNA can show you in this interactive Xenium web demo.

Get to know the Xenium platform

Explore the unique platform features, from padlock chemistry to panels, that power the ultimate single cell spatial biology experience.

Grant writing assistance

Get the information you need to write grants featuring Xenium experiments (including technology overview, benchmarking data, and more).

See what Xenium users are saying

Unlock the full spectrum of biology

Build on your Xenium Spatial insights with comprehensive, whole transcriptome single cell and spatial analysis.

See how researchers used Chromium, Visium, and Xenium assays to study human lung development
Platform

Chromium Single Cell platform

Learn more

Xenium Spatial platform

See Xenium panels

Visium Spatial platform

Learn more
When to use
Comprehensive single cell data Ideal for deep characterization of cell populations and states.
High-resolution discovery Understand complex tissues, neighborhoods, and cell to cell interactions. Integration with other spatial-omics, histology, and morphology.
Why use
Unbiased single cell discovery High per-gene sensitivity
Single cell spatial discovery High per-gene sensitivity
Expanded spatial discovery
Applications
Whole transcriptome gene expression Protein TCR, BCR CRISPR ATAC
Targeted gene expression (up to 5,000 genes) Multiomic gene and protein expression (up to 480 genes and 27 proteins)
Whole transcriptome gene expression
Resolution
Single cell
Subcellular
Single cell–scale
Data readout
NGS-based
Imaging-based
NGS-based
Sample compatibility
Single cell or nuclei suspensions from fresh, frozen, or FFPE samples
Fresh frozen FFPE
FFPE Fresh frozen Fixed frozen

Vision Diagnostic

Bring Xenium to your laboratory.

Talk to our scientific and technical team about product selection, panels, applications, pricing and implementation support.