Fill-Finish Solution

Increase drug product recovery

Fill-finish is the final step in vaccine or biologic production, where minimizing loss and avoiding contamination are critical. Filling assemblies, consisting of a surge bag, tubing, and filling needles, are delivered into the isolator through a secure port using a beta bag.

Thermo Fisher Scientific offers configurable fill-finish solutions compatible with leading isolator manufacturers, an ideal choice for BioPharma and CDMOs. As a widely used consumables supplier for IMA TILE-X, we offer trusted support to help ensure integrity, excellent lead times, and a range of single-use consumables for compounding, sterile filtration (PUPSIT), and aseptic filling applications.

Our team of specialists can assist with customizable, engineered-to-order solutions to meet your specific needs, helping to ensure high product quality and optimized workflow.

features

Thermo Scientific fill-finish solutions offer

Thermo Fisher is now the widely used fill-finish supplier for the IMA TILE-X gloveless isolator. The Thermo Scientific Fill Finish Solution offers superior helium integrity testing and exceptional product recovery, enabling high-performance results. Designed for seamless compatibility with IMA TILE-X gloveless technology, it helps deliver excellent reliability and efficiency.

Increased product recovery

Labtainer Pro BioProcess Container (BPC) design enables optimal drainage with very high product recovery

Integrity assurance

100% assembly helium integrity test with 10 μm detection limit to help minimize leakage risk

Improved setup process

BioTitan Retention Device can simplify unpacking steps, compared to traditional cable ties, and helps reduce risk of leaks and connection failures

Exceptional lead times

Standard and configurable product design

High-quality film

Rigorously tested single-use Aegis 5-14 film for durability

Single-use assemblies for fill-finish processes

The fill-finish product family offers configurable, single-use assemblies from a standard component catalog for drug product final fill applications.

 

Compounding assemblies

Discover our selection of 2D and 3D bags designed for powders and liquids, with optional integrated filtration. These purpose-built bags and tubing maintain sterility and support maximum product recovery. Each bag is pressure tested with helium gas to help ensure product integrity.

Filtration assembly

Pre-Use Post-Sterilization Integrity Testing (PUPSIT) compliant double filtration assemblies to support final fill-finish. Available to support a variety of volumes across your workflow.

Filling assemblies

Built from high integrity components designed to minimize leak and contamination risk. Filling assemblies are comprised of surge bags, tubing, and filling needles that are aseptically delivered into the isolator through a beta bag.

Experience the fill-finish 3D tour

Explore this interactive tool to discover how our fill-finish solution can significantly enhance drug product recovery and provide exceptional lead times. Our systems are designed to be highly customizable and configurable to meet diverse requirements for optimal efficiency and quality in aseptic filling operations.

Featured fill-finish components

Labtainer Pro System

The Labtainer Pro is a single-use bioprocess container system designed for secure fluid handling and storage with minimal product retention. It integrates the BioTitan retention device for enhanced reliability and ease of use.

BioTitan Retention Device

The BioTitan Retention Device helps enhance single-use assemblies with a secure 360-degree seal, replacing traditional cable ties. With zero leaks reported as of 2021, the BioTitan device helps eliminate sharp edges and simplify setup for improve reliability and integrity in bioprocessing workflows.

Beta bag

vailable in a variety of bag sizes and transfer port diameters to help securely deliver your fill-finish assembly into the isolator without introducing contamination. Updated packaging is designed to prevent accidental damage and reduce waste.

Related products

Bioprocessing films

Bioprocessing films are critical in the bioprocessing workflow, providing sterile, durable containment from cell cultivation and media storage to fill finish. We offer high-quality, single-use films that help ensure product integrity, reduce contamination risk, and enhance efficiency.

Sterilizing Grade Filters

Integrate LifeASSURE sterilizing grade filters into your Thermo Scientific single-use assemblies—offering you the confidence of quality filtration performance, improved workflow integration, and reliable global supply.
 

Explore BioProcess Insights

The Bioprocess Insights Hub by Thermo Fisher Scientific is designed for biomanufacturing professionals, offering educational resources to optimize single-use bioprocessing workflows. It features articles, guides, and case studies on topics such as assembly design, contamination mitigation, and technology transfer. Resources include application notes, brochures, white papers, videos, and webinars, covering areas like process optimization, scalability, quality, and sustainability.

 

resources

Additional bioprocessing resources

Bioprocessing Blogs

Explore our collection of information and insights to support your drug development journey.

Events and webinars

Join us to learn, evaluate, and connect with experienced professionals in the field.

Bioprocessing resources

Find product guides, tools, and reference materials to help plan and optimize your workflows.

Contact us

Connect with a Bioprocessing representative or request more info.